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When using manufactured solid dosage forms to prepare a solution or aqueous suspension, the compounder is also to consider factors such as hydrolysis and the freeze-thaw property of the final preparation before assigning a beyond-use date.

In assigning a beyond-use date for a compounded drug preparation, in addition to using all available stability information, the compounder is also to use his or her pharmaceutical education and experience.

Areas used for sterile preparations are to be separated and distinct from the nonsterile compounding area (see Compounding areas are to be maintained in a clean and sanitary condition.

Adequate washing facilities are to be provided, including hot and cold water, soap or detergent, and air driers or single-service towels.

Compounding and packaging of sterile drugs, such as ophthalmic solutions, will require strict adherence to guidelines presented in the general test chapter The beyond-use date is the date after which a compounded preparation is not to be used and is determined from the date the preparation is compounded.

Because compounded preparations are intended for administration immediately or following short-term storage, their beyond-use dates may be assigned based on criteria different from those applied to assigning expiration dates to manufactured drug products.

All equipment is to be constructed so that surfaces that contact pharmaceutical components, in-process materials, or finished preparations are not reactive, additive, or adsorptive to avoid altering the safety, identity, strength, quality, or purity of the preparation.Compounders must be familiar with statutes and regulations that govern compounding because these requirements vary from state to state.), official standards, and relevant scientific data and information.Compounders engaging in compounding should have to continually expand their compounding knowledge by participating in seminars, studying appropriate literature, and consulting colleagues.Container–drug interaction is to be considered with substances such as phenolic compounds and sorptive materials (e.g., polypeptides and proteins).Assurance of sterility in a compounded sterile preparation is mandatory.

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At all steps in the compounding, dispensing, and storage process, the compounder is to observe the compounded drug preparation for signs of instability.

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